Anti-Cancer Activities of HDAC Inhibitors

Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population

N Hein, DP Cameron, KM Hannan, NYN Nguyen, CY Fong, J Sornkom, M Wall, M Pavy, C Cullinane, J Diesch, JR Devlin, AJ George, E Sanij, J Quin, G Poortinga, I Verbrugge, A Baker, D Drygin, SJ Harrison, JD Rozario

2017-05-25

Despite the development of novel drugs, the prospects for many patients with acute myeloid leukemia (AML) remain dismal. This stud..

Cell cycle and growth stimuli regulate different steps of RNA polymerase I transcription

SS Hung, A Lesmana, A Peck, R Lee, E Tchoubrieva, KM Hannan, J Lin, KE Sheppard, K Jastrzebski, LM Quinn, LI Rothblum, RB Pearson, RD Hannan, E Sanij

2017-05-15

Transcription of the ribosomal RNA genes (rDNA) by RNA polymerase I (Pol I) is a major control step for ribosome synthesis and is ..

The potential of targeting ribosome biogenesis in high-grade serous ovarian cancer

S Yan, D Frank, J Son, KM Hannan, RD Hannan, KT Chan, RB Pearson, E Sanij

2017-01-20

Overall survival for patients with ovarian cancer (OC) has shown little improvement for decades meaning new therapeutic options ar..

Combination therapy targeting ribosome biogenesis and mRNA translation synergistically extends survival in MYC-driven lymphoma

JR Devlin, KM Hannan, N Hein, C Cullinane, E Kusnadi, PY Ng, AJ George, J Shortt, MJ Bywater, G Poortinga, E Sanij, J Kang, D Drygin, S O’Brien, RW Johnstone, GA McArthur, RD Hannan, RB Pearson

2016-01-01

Ribosome biogenesis and protein synthesis are dysregulated in many cancers, with those driven by the proto-oncogene c-MYC characte..

Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling

J Quin, KT Chan, JR Devlin, DP Cameron, J Diesch, C Cullinane, J Ahern, A Khot, N Hein, AJ George, KM Hannan, G Poortinga, KE Sheppard, KK Khanna, RW Johnstone, D Drygin, GA McArthur, RB Pearson, E Sanij, RD Hannan

2016-01-01

RNA polymerase I (Pol I)-mediated transcription of the ribosomal RNA genes (rDNA) is confined to the nucleolus and is a rate-limit..

Synergistic inhibition of ovarian cancer cell growth by combining selective PI3K/mTOR and RAS/ERK pathway inhibitors

KE Sheppard, C Cullinane, KM Hannan, M Wall, J Chan, F Barber, J Foo, D Cameron, A Neilsen, P Ng, J Ellul, M Kleinschmidt, KM Kinross, DD Bowtell, JG Christensen, RJ Hicks, RW Johnstone, GA McArthur, RD Hannan, WA Phillips

2013-12-01

Background Ovarian cancer is the major cause of death from gynaecological malignancy with a 5 year survival of only ∼30% due to re..

AKT signalling is required for ribosomal RNA synthesis and progression of Eμ-Myc B-cell lymphoma in vivo

JR Devlin, KM Hannan, PY Ng, MJ Bywater, J Shortt, C Cullinane, GA McArthur, RW Johnstone, RD Hannan, RB Pearson

2013-11-01

The dysregulation of PI3K/AKT/mTORC1 signalling and/or hyperactivation of MYC are observed in a high proportion of human cancers, ..

The mTORC1 inhibitor everolimus prevents and treats Eμ-Myc lymphoma by restoring oncogene-induced senescence

M Wall, G Poortinga, KL Stanley, RK Lindemann, M Bots, CJ Chan, MJ Bywater, KM Kinross, MV Astle, K Waldeck, KM Hannan, J Shortt, MJ Smyth, SW Lowe, RD Hannan, RB Pearson, RW Johnstone, GA McArthur

2013-01-01

MYC deregulation is common in human cancer. IG-MYC translocations that are modeled in EμMyc mice occur in almost all cases of Burk..